Staphylococcal and Streptococcal Superantigens: Basic Biology of Conserved Protein Toxins
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چکیده
منابع مشابه
Staphylococcal and Streptococcal Superantigens: Basic Biology of Conserved Protein Toxins
Staphylococcus aureus and Streptococcus pyogenes are gram-positive bacteria that possess great pathogenic potential in humans, causing numerous maladies such as arthritis, cutaneous infections, endocarditis, enterocolitis, food poisoning, pharyngitis, pneumonia, rheumatic fever, surgical site infections, and toxic shock. These prevalent pathogens produce various virulence factors that include t...
متن کاملDisruption of wall-less bacteria by streptococcal and staphylococcal toxins.
Bernheimer, Alan W. (New York University School of Medicine, New York, N.Y.). Disruption of wall-less bacteria by streptococcal and staphylococcal toxins. J. Bacteriol. 91:1677-1680. 1966.-Earlier studies demonstrating that staphylococcal alpha-toxin and streptolysin S have the capacity to lyse protoplasts and spheroplasts of certain species of bacteria and Mycoplasma have been extended to enco...
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Staphylococcal enterotoxins are a family of structurally related proteins that are produced by Staphylococcus aureus. In addition to their role in the pathogenicity of food poisoning, these microbial superantigens have profound effects on the immune system, which makes them useful tools for understanding its mechanism of action. These molecules (24-30 kDa) are highly hydrophilic and exhibit low...
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Staphylococcus aureus is the leading cause of bone and joint infections (BJIs). Staphylococcal pathogenesis involves numerous virulence factors including secreted toxins such as pore-forming toxins (PFTs) and superantigens. The role of these toxins on BJI outcome is largely unknown. In particular, few studies have examined how osteoclasts, the bone-resorbing cells, respond to exposure to staphy...
متن کاملSoluble T Cell Receptor Vβ Domains Engineered for High-Affinity Binding to Staphylococcal or Streptococcal Superantigens
Staphylococcus aureus and group A Streptococcus secrete a collection of toxins called superantigens (SAgs), so-called because they stimulate a large fraction of an individual's T cells. One consequence of this hyperactivity is massive cytokine release leading to severe tissue inflammation and, in some cases, systemic organ failure and death. The molecular basis of action involves the binding of...
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ژورنال
عنوان ژورنال: The Open Toxinology Journal
سال: 2013
ISSN: 1875-4147
DOI: 10.2174/1875414701003010069